Acceclowoc-SP Tablet

Acceclowoc SP Tablet is the combination three drugs that are paracetamol, aceclofenac, and serratiopeptidase which are utilized to treat agony, solidness, and enlarging at joints due to ankylosing spondylitis (a kind of joint pain that causes lower back torment influencing the spine and huge joints), osteoarthritis (a sort of joint pain that happens when adaptable tissue at the finishes of your bones wears out) and rheumatoid joint inflammation (an immune system problem influencing many joints, remembering those for the hands and feet).

It is used to get rid of migraines, toothaches, spinal pains, feminine agony, injuries, and strains. This medication prevents the release of enzymes that causes pain and swelling from being released.

Paracetamol

It is the de-ethylated active metabolite of phenacetin. The central analgesic action of paracetamol acts by raising pain threshold with weak peripheral anti-inflammatory component. It has additive analgesic action. Paracetamol is spontaneous antipyretic.

Paracetamol has negligible anti inflammatory action as weak inhibitor of PG synthesis in peripheral tissues, but is more active on COX 1or COX 2 in the brain.

It is unable to inhibit COX in the presence of peroxides which are generated at sites of inflammation which opens divergence in its analgesic, antipyretic and anti inflammatory properties, as peroxides are actually not present in the brain, so is no effective at that site.

The ability of paracetamol to inhibit COX-3 also accounts for its analgesic-antipyretic action. It acts as antipyretic by inhibiting the release or synthesis of Prostaglandin (PG) hormone which is actually  released by pyrogen causing increase in body temperature.

Aceclofenac

It inhibits PG synthesis and is preferentially COX-2 inhibitors. It works by obstructing the impacts of cyclooxygenase (COX) proteins, which are liable for delivering prostaglandins that add to irritation and agony flagging.

Aceclofenac goes through oxidative digestion to hydroxy metabolites as well as formation to glucuronic corrosive, sulfate, and taurine. The essential metabolite is 4′- hydroxy diclofenac which is created by CYP2C9 enzyme. 

Swelling and pain

Everybody experiences inflammation or swelling as part of the immune system’s response to protect the body from infection, injury, or disease.

Acceclowoc SP Tablet works by the breakdown of proteins that are available at the site of the expanding and by hindering specific synthetic couriers in the cerebrum that cause fever and agony.

As a result, it is used to treat muscle injuries, post-surgical conditions, joint conditions, and other conditions that cause swelling and pain.

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Rheumatoid arthritis

Rheumatoid joint pain (RA) happens when your body’s insusceptible framework goes after the covering of your joints causing expanding and torment at joints.

In RA similar joints on the two sides of the body are impacted. This assists with recognizing RA from osteoarthritis.

Acceclowoc SP Tablet is utilized to ease enlarging and torment in the joints because of RA.

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Ankylosing spondylitis

Ankylosing spondylitis is a sort of joint pain that principally influences the spine and makes a portion of the little bones combine.

Ankylosing spondylitis-related stiffness and pain, particularly in the lower back, hip, and pelvis, can be alleviated with the help of Acceclowoc SP Tablet.

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Side effects

• Nausea
• Vomiting
• stomach pain
• indigestion
• heartburn
• increased liver enzymes
• dizziness
• drowsiness
• diarrhea 
• Fever
• Allergic skin reaction
• Mouth sores
• Bloody and cloudy urine
• Stomach irritation
• Fatigue

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Aceclofenac IP      100mg

Paracetamol IP       325mg

Serratiopeptidase   10mg (as enteric coated contains Serratiopeptidase 20,000 units)     

Excipients                 q.s.

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• Do not consume alcohol as it may lower blood pressure, dizziness, headache and altered heart rate.
• There are chances of harm to foetus during pregnancy and also during breastfeeding, so one should avoid.
• Consume drug with food and milk. Don’t consume empty stomach as it may cause stomach irritation.
• Don’t consume more than prescribed dose
• Don’t use if you have stomach or intestinal bleeding as it may cause dizziness or drowsiness.
• Don’t consume if you have asthma, liver or kidney problems, even if you have history of any of mentioned problem.

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